Funded Research
Our annual funding round is designed to support bright young researchers, as well as established institutions, as they strive to make the kind of life-changing breakthrough our diabetes community is hoping for.
Our first research award was made in 1999 for a small equipment grant and since that time, we have committed more than £12 million to diabetes research in the UK and as part of the International Diabetes Wellness Network, around the world.
To read more about our research strategy, click here.
2002
Research Grant, Open Funding
Hypoglycaemia and cardiac arrhythmia in type 1 diabetes - a study using ambulatory blood glucose and ECG monitoring
Recipient: Dr Geoffrey Gill
Institution: University of Liverpool
City: Liverpool
Amount: £20,000
- Description - click here to read
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Diabetes can be associated with disturbances of heart rhythm and this may be caused by low blood glucose levels. This research is investigating this problem using sophisticated monitoring equipment which can measure heart rhythm and simultaneous blood glucose levels while the patient goes about their usual daytime activities.
2002
Research Grant, Open Funding
Mechanism of action of Grb10, a negative regulator of insulin signalling & a potential drug target for treating Type 2 diabetes
Recipient: Prof. Ken Siddle
Institution: University of Cambridge
City: Cambridge
Amount: £29,662
- Description - click here to read
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Professor Ken Siddle and his team are studying a group of proteins (Grbs) which seem able to blunt the action of insulin by binding directly to the insulin receptor protein and inhibiting the signals the receptor would normally send to regulate a cell's metabolism. There is some evidence that these Grb proteins are more abundant in tissues of diabetics, and they might contribute to the "insulin resistance" that characterises the diabetic state. If we understand more about the way Grbs work we might be able to target them with drugs to improve insulin sensitivity.
2002
Research Grant, Open Funding
Molecular mechanisms contributing to the pathogenesis of insulin resistance in skeletal muscle
Recipient: Dr Hari Hundal
Institution: University of Dundee
City: Dundee
Amount: £29,681
- Description - click here to read
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Molecular mechanisms contributing to the pathogenesis of insulin resistance in skeletal muscle.
2002
Research Grant, Open Funding
Nephrin phosphorylation & podocyte structure in diabetic rats - low birth weight study
Recipient: Dr Kathryn White
Institution: University of Newcastle
City: London
Amount: £31,618
- Description - click here to read
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Kidney disease is a major complication of diabetes and is diagnosed by the presence of protein in the urine. This study has examined specific structural components of the kidney in an attempt to get a better understanding of how the protein is lost.
2002
The Professor David Matthews Non-Clinical Fellowship
The Generation of functional islets of Langerhans from stem cells in vitro
Recipient: Dr Chris Burns
Institution: King's College London
City: London
Amount: £155,515
- Description - click here to read
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Type 1 diabetes is caused by the selective destruction of the insulin-secreting beta-cells of the pancreas. Therapeutic replacement of beta-cells can cure diabetes but the supply of primary tissue from human donors is limiting. This research investigates the potential of pluripotent stem cells, from various starting populations, to differentiate into functional beta-cells, with the ultimate goal of offering new therapeutic possibilities for the treatment of Type 1 diabetes.
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