Funded Research
Our annual funding round is designed to support bright young researchers, as well as established institutions, as they strive to make the kind of life-changing breakthrough our diabetes community is hoping for.
Our first research award was made in 1999 for a small equipment grant and since that time, we have committed more than £12 million to diabetes research in the UK and as part of the International Diabetes Wellness Network, around the world.
To read more about our research strategy, click here.
2003
Research Grant, Open Funding
Adapting the HOMA model to estimate insulin sensitivity and beta cell function in people with Type 2 diabetes mellitus treated with insulin
Recipient: Prof. Rury Holman/Dr Richard Stevens
Institution: University of Oxford
City: Oxford
Amount: £29,983
- Description - click here to read
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"Blood glucose levels depend on how much insulin the body can make, and how the body responds to insulin. These can be estimated simply with a blood sample and the HOMA computer program. Currently, HOMA does not work for people with diabetes who take insulin. This project will produce a new version to make this possible. This will be used by researchers, developing treatments for diabetes."
2003
Research Grant, Open Funding
Finding the genes in human adipose tissue that cause insulin resistance
Recipient: Prof. Peter Arner/Prof. Keith Frayn
Institution: Karolinska Institute/Oxford
City: Oxford
Amount: £30,000
- Description - click here to read
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Professors Arner and Frayn have performed microarrays on human adipose tissue of lean and obese subjects and found a novel gene strongly associated with insulin resistance. The function of this gene in human fat cells is currently under investigation.
2003
Sutherland-Earl Clinical Fellowship
Is the abnormal postprandial suppression of hepatic glucose production in type 2 diabetes reversible by decreasing intrahepatic triglyceride stores?
Recipient: Dr B. Ravikumar
Institution: University of Newcastle
City: Newcastle
Amount: £100,000
- Description - click here to read
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The liver usually produces glucose as needed by the body. This production is normally stopped after meals. However, in type 2 diabetes, the liver fails to stop producing glucose and this adds to the glucose absorbed from food, causing higher blood glucose levels. Previous research has shown that the impaired regulation of glucose controlling hormones (insulin and glucagon) and excess fat stored in the liver are responsible for this increased glucose production. We aim to investigate the relative importance of the hormones and the hepatic fat content on the regulation of glucose production. By using a combination of tablets to reduce hepatic fat content, we will examine whether this reduces glucose production. In a separate study, we will use an experimental hormone infusion to normalise the glucose controlling hormones and study its effect on glucose production. Finally, the effect of these factors will be examined in people with impaired glucose tolerance, a condition that precedes the development of overt diabetes.
2003
Research Grant, Open Funding
The role of Synaptotagmins in Insulin-stimulated Glucose Transport in the Adipocyte
Recipient: Dr Steven Miller
Institution: University of Glasgow
City: Glasgow
Amount: £27,000
- Description - click here to read
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The role of Synaptotagmins in Insulin-stimulated Glucose Transport in the Adipocyte.
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