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Funded Research

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    • 2002
      Research Grant, Open Funding

      Hypoglycaemia and cardiac arrhythmia in type 1 diabetes - a study using ambulatory blood glucose and ECG monitoring

      Recipient:
      Dr Geoffrey Gill
      Institution:
      University of Liverpool
      City:
      Liverpool
      Amount:
      £20,000
      Description: Diabetes can be associated with disturbances of heart rhythm and this may be caused by low blood glucose levels. This research is investigating this problem using sophisticated monitoring equipment w...
      Description: Diabetes can be associated with disturbances of heart rhythm and this may be caused by low blood glucose levels. This research is investigating this problem using sophisticated monitoring equipment which can measure heart rhythm and simultaneous blood glucose levels while the patient goes about their usual daytime activities.
    • 2002
      Research Grant, Open Funding

      Mechanism of action of Grb10, a negative regulator of insulin signalling & a potential drug target for treating Type 2 diabetes

      Recipient:
      Prof. Ken Siddle
      Institution:
      University of Cambridge
      City:
      Cambridge
      Amount:
      £29,662
      Description: Professor Ken Siddle and his team are studying a group of proteins (Grbs) which seem able to blunt the action of insulin by binding directly to the insulin receptor protein and inhibiting the signals ...
      Description: Professor Ken Siddle and his team are studying a group of proteins (Grbs) which seem able to blunt the action of insulin by binding directly to the insulin receptor protein and inhibiting the signals the receptor would normally send to regulate a cell's metabolism. There is some evidence that these Grb proteins are more abundant in tissues of diabetics, and they might contribute to the "insulin resistance" that characterises the diabetic state. If we understand more about the way Grbs work we might be able to target them with drugs to improve insulin sensitivity.
    • 2002
      Research Grant, Open Funding

      Molecular mechanisms contributing to the pathogenesis of insulin resistance in skeletal muscle

      Recipient:
      Dr Hari Hundal
      Institution:
      University of Dundee
      City:
      Dundee
      Amount:
      £29,681
      Description: Molecular mechanisms contributing to the pathogenesis of insulin resistance in skeletal muscle...
      Description: Molecular mechanisms contributing to the pathogenesis of insulin resistance in skeletal muscle
    • 2002
      Research Grant, Open Funding

      Nephrin phosphorylation & podocyte structure in diabetic rats - low birth weight study

      Recipient:
      Dr Kathryn White
      Institution:
      University of Newcastle
      City:
      London
      Amount:
      £31,618
      Description: Kidney disease is a major complication of diabetes and is diagnosed by the presence of protein in the urine. This study has examined specific structural components of the kidney in an attempt to get ...
      Description: Kidney disease is a major complication of diabetes and is diagnosed by the presence of protein in the urine. This study has examined specific structural components of the kidney in an attempt to get a better understanding of how the protein is lost.
    • 2002
      The Professor David Matthews Non-Clinical Fellowship

      The Generation of functional islets of Langerhans from stem cells in vitro

      Recipient:
      Dr Chris Burns
      Institution:
      King's College London
      City:
      London
      Amount:
      £155,515
      Description: Type 1 diabetes is caused by the selective destruction of the insulin-secreting beta-cells of the pancreas. Therapeutic replacement of beta-cells can cure diabetes but the supply of primary tissue fr...
      Description: Type 1 diabetes is caused by the selective destruction of the insulin-secreting beta-cells of the pancreas. Therapeutic replacement of beta-cells can cure diabetes but the supply of primary tissue from human donors is limiting. This research investigates the potential of pluripotent stem cells, from various starting populations, to differentiate into functional beta-cells, with the ultimate goal of offering new therapeutic possibilities for the treatment of Type 1 diabetes.

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